Background: Universal Health Insurance is a governmental tool for financial risk management in healthcare systems, presented as an alternative to mitigate individual economic impact, guarantee access to health, and efficiently distribute public expenditure resources. It is based on a revenue model, either public and/or private, to achieve health coverage that distributes financial risk among all insured members, and may even encompass those outside the system. The aim of this work is to conduct a systematic and comparative analysis, considering the experiences of different countries that have adopted Universal Health Insurance or similar systems, in contrast to the characteristics of Argentina, to determine potential challenges and proposals that may arise in the hypothetical case of implementing such a mechanism in the country. Material and methods: A systematic, ubiquitous, atemporal, and/or diachronic review of publications on obstacles, proposals, and outcomes related to public policies on universal health insurance or similar initiatives was conducted. This review comprehend different countries and aimed to compare potential coincidences, differences, and intermediate points with organizational factors in Argentina. Results: 60 studies were included from 25 countries, where key factors in the implementation of Universal Health Insurance were identified: Willingness to Pay (WTP); Informal and unemployed workers; Social, ethical, and political considerations; Segmentation; Tools on demand; Supervision of health centers and insurance companies; Designs and structures; Other considerations. Conclusion: By considering the experiences of other countries with similar socioeconomic characteristics, it is possible to develop proposals and design a model of Universal Health Insurance in Argentina that ensures quality, equity, reduces individual risk, and contributes to financially sustainable support over time.